Download PDF by Jeffrey V. Ravetch (auth.), Max D. Cooper M.D., Toshiyuki: Activating and Inhibitory Immunoglobulin-like Receptors

By Jeffrey V. Ravetch (auth.), Max D. Cooper M.D., Toshiyuki Takai Ph.D., Jeffrey V. Ravetch M.D., Ph.D. (eds.)

A notable spectrum of novel immunoreceptors sharing similar immunoglobulin-like domain names and signaling capability has been pointed out lately. those receptors have attracted common curiosity simply because they resemble the TCR, BCR, and FcR complexes of their skill to function activating or inhibitory receptors at the cells that undergo them. furthermore, they're good situated to impact either innate and adaptive immunity. the complete variety of ligands for those new receptor households continues to be no longer recognized, and figuring out in their physiological roles is much from entire. This quantity is the 1st try to summarize and spotlight all recognized features of immunoglobulin-like receptors, delivering a topical evaluate of the jobs and attribute beneficial properties of the immunoglobulin-like receptors and comparable molecules within the immune method. Researchers in immunology, molecular biology, telephone biology, scientific drugs, and pharmacology will locate this ebook invaluable.

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J Immunol 145:2353-2358 5 Regulation of human FeaR gene expression Toshibumi Shimokawa' :"", Toshinao Tsuge' :", and Chisei Ral,2,4 'Allergy Resear ch Center. 20 epartmem t of Immunology. and ' Oepartment of Nephrology. Juntendo Univer sity School of Medicine. 2-1-1 Hongo, Bunkyo-ku , Tokyo 113-8421 . Japan ' CREST. Japan Science and Technology Corporat ion (JST). Kawaguchi-city, Japan Summary. The Fe receptor for IgA (Fcnk, CD89) is expressed exclusively on human phagocytic cells including monocytes/macrophages, neutrophils, and eosinophils, and is capable of triggering various IgA-mediated effector functions , Altered FcaR expression has been reported in several diseases such as IgA nephropathy (IgAN) and allergic diseases, suggesting a role for FcaR in pathogenesis of diseases , The description of a promoter that directs tissue- or cell type-specific transcription could offer new insights into the mechanisms underlying aberrant gene expression associated with diseases , Here we show that at least two transcription factors , CIEBPa and an Ets-like factor, are functionally important for myeloid-specific expression of the FeaR gene , In addition, the FeaR promoter could be transactivated by PU, I, an Ets protein family member which has been shown to regulate the promoters of many myeloid-specific genes, Furthermore, in the FeaR promoter region there are two novel functional polymorphisms (T to C transition) that are associated with IgAN.

1996; Kashem et al. 1997), decreased FcaR expression of circulating monocytes has recently been implicated in IgAN (Grossetete et al. 1998; Launay et al. 2000). In this context, a soluble form of FcaR has more recently been identified in IgAN patient serum as a putative pathogenic factor, and shown to be generated by proteolytic shedding in respon se to IgA (Launay et al. 2000) . Therefore, decreased FcaR expression on monocytes could result from the release of soluble FcaR from the cell surface.

Division of Rheumatology. Departments of Medicine and of Pathology and Immunology. Box 8045. Washington University School of Medicine. S\. Louis. MO 63110. USA Summary. Murine natural killer (NK) cells express inhibitory receptors belonging to the C-type lectin-like (Ly-49. CD94/NKG2) and Ig-superfamily related (gp49) receptors . The murine gp49B receptor displays structural homology with human killer inhibitory receptors (KIR) and other Ig-Iike receptors . By contrast to most of these receptors.

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