Download e-book for kindle: Airways Smooth Muscle: Peptide Receptors, Ion Channels and by Douglas W. P. Hay (auth.), Dr. David Raeburn, Dr. Mark A.

By Douglas W. P. Hay (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)

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Extra info for Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction

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Early studies provided evidence that ET-l-induced contraction in human airways is not associated with extracellular Ca2+ influx via voltage-sensitive channels [131, 150, 252]. However, a more recent preliminary study suggests that a component of the response to ET-1 in human bronchus was mediated by this mechanism [253]. In addition, it was hypothesized that, as proposed for rat trachea [142, 144], different signal transduction pathways mediate ETA and ET B receptor activation in human bronchus [253].

18. Yoshimi H, Hirata Y, Fukuda Y, Kawano Y, Emori T, Kuramochi M et al. Regional distribution of immunoreactive endothelin in rats. Peptides 1989; 10: 805-8. 38 D. W. P. Hay 19. Nunez DJR, Brown MJ, Davenport AP, Neylon CB, Schofield JP, Wyse RK. Endothelin-I mRNA is widely expressed in porcine and human tissues. J. Clin. Invest. 1989; 85: 1537-41. 20. Rozengurt N, Springall DR, Polak JM. Localization of endothelin-like immunoreactivity in airway epithelium of rats and mice. J. Pathol. 1990; 707: 5-8.

86. Adachi M, Yang Y-Y, Furuichi Y, Miyamoto C. Cloning and characterization of cDNA encoding human A-type endothelin receptor. Biochem. Biophys. Res. Comm. 1991; 180: 1265-72. 87. Cyr C, Huebner K, Druck T, Kris R. Cloning and chromosomal localization of a human endothelin ETA receptor. Biochem. Biophys. Res. Comm. 1991; 181: 184-90. 88. Hosoda K, Nakao K, Arai-H, Suga S-i, Ogawa Y, Mukoyama M et al. Cloning and expression of human endothelin-I receptor eDNA. FEBS Letts. 1991; 287: 23-6. 89. Nakamuta, M, Takayanagi R, Sakai Y, Sakamoto S, Hagiwara H, Mizuno T, et al.

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