New PDF release: Biological Markers of Alzheimer’s Disease

By J. R. Atack (auth.), Prof. François Boller, Prof. Robert Katzman, Prof. André Rascol, Prof. Jean-Louis Signoret, Dr. Yves Christen (eds.)

This quantity offers the lawsuits of the symposium held in Toulouse on April 24, 1989, at the subject "Biological Markers of Alzheimer's affliction. " This sym­ posium was once the fourth of a continual and winning sequence of Colloques Medecine et Recherche geared up via the Fondation IPSEN pour l. a. Recherche Therapeutique, addressing a number of elements of up to date examine within the box of Alzheimer's disorder (AD). The sequence begun in September 1987 with "Im­ munology and Alzheimer's Disease," 6 months later in Paris through "Gene­ tics and Alzheimer's illness" and in September 1988 in Montpellier via "Neuronal Grafting and Alzheimer's sickness. " the current symposium was once geared up for the aim of accumulating the most up-tp-date rules touching on organic markers of advert. The papers offered at this symposium can be approximately subdivided into 3 teams. the 1st offers with the markers of advert on the point of the mind itself. those markers are studied both during the cerebrospinal fluid or via thoughts reminiscent of nuclear magnetic resonance (NMR) - techniques which respectively target at demonstrating the cerebral adjustments indicated via the particles because of the sickness, or learning the potential neurochemical abnormalities that take place within the past phases of AD.

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As mentioned above, these modifications appear to render normally soluble proteins insoluble in most aqueous media; whether or not modified forms of tangle proteins exist in cerebrospinal fluid is yet to be established. Perhaps the most serious problem in the use of tangle-related antibodies for the diagnosis of Alzheimer's disease is the observation that many elderly demented individuals have only a few tangles in the hippocampus, and very few in other brain regions, despite the presence of numerous senile plaques.

Tau Phosphorylation Two features appear to predominate in studies of the posttranslational modifications of tau. One is that phophorylation is the only known posttranslational modification of tau. A second feature is that conformational changes, perhaps linked to phosphorylation events, must be considered in the design of protein level tau probes, and these changes are likely to have both biological and pathological implications. Regarding tau phosphorylation the following observations are found in the literature.

In three separate analyses the concentration ofPHF antigens was elevated in the CSF of AD patients. Although the range of values overlaps with those of other neurological diseases, the higher values may serve as a useful adjunct to the diagnosis and therapeutic response when combined with appropriate clinical neuropsychological findings. Because of the complex nature of the pathology, it is possible that no single biochemical marker will be specific for the diagnosis of AD. Our preliminary finding that amyloid beta-protein is present in AD CSF will permit the correlation of the concentrations of both PHF antigens and beta-protein in CSF of AD patients.

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