By Christopher P. Duggan, Kathleen M. Gura, Tom Jaksic
"This reference offers a present, multidisciplinary method of the care of sufferers with intestinal failure. It comprises extensive dialogue on scientific and dietary matters specially relative to teenagers with intestinal failure. It provides info on transplantation, yet emphasizes rehabilitation. themes disguise etilogy/epidemiology, pathophysiology, and medical overview of intestinal failure in adults and pediatrics; scientific and surgical administration; prevention and remedy of issues of intestinal failure; nursing administration; rising diagnostic and healing equipment; and long-term care. it really is written via specialists in meals, gastroenterology and pediatrics, pharmacy, in addition to gastrointestinal surgery"--Provided by means of publisher. Read more...
content material: Pt. 1. Intestinal failure --
pt. 2. clinical and surgical administration --
pt. three. Prevention and remedy of problems of intestinal failure --
pt. four. Nursing administration --
pt. five. rising diagnostic and healing equipment --
pt. 6. long term care.
summary: "This reference presents a present, multidisciplinary method of the care of sufferers with intestinal failure. It contains in depth dialogue on clinical and dietary concerns specifically relative to youngsters with intestinal failure. It provides info on transplantation, yet emphasizes rehabilitation. subject matters disguise etilogy/epidemiology, pathophysiology, and medical overview of intestinal failure in adults and pediatrics; clinical and surgical administration; prevention and therapy of issues of intestinal failure; nursing administration; rising diagnostic and healing equipment; and long-term care. it truly is written through specialists in foodstuff, gastroenterology and pediatrics, pharmacy, in addition to gastrointestinal surgery"--Provided via writer
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Additional resources for Clinical management of intestinal failure
24,25 The key to this process in animal models is the provision of enteral nutrition immediately postsurgical resection which stimulates gut function and release of gut hormones. 9,14,15,17,26 The mechanism of increased expression of these genes is still being clarified. In humans, after significant bowel resection and depending on which portions of bowel are removed, the remainder of the reconnected bowel will begin to adapt or compensate over time. Enteral feeding should be resumed as soon as possible when safe to stimulate adaptation as the process of digestion stimulates various hormones that when combined likely have a trophic effect on the remaining bowel.
This causes acetylcholine and the neuropeptide gastrin-releasing peptide (GRP) to be released from the vagus nerve. The vagus nerve directly innervates gastrin (G) cells and parietal cells. G cells are predominantly, located in the antrum, while parietal cells are predominantly located in the body and fundus. Acetylcholine acts on parietal cell M1 receptors and stimulates hydrochloric acid (HCl) secretion, while GRP stimulates G cells to release gastrin, which in turn stimulates parietal cells to secrete more acid.
However, patients with <100 cm of jejunum with unrestricted diets cannot reabsorb these large volumes of fluid, which can be hyperosmolar further increasing gut losses. Thus, they excrete more fluid than absorb secondary to net secretion of salt and fluid not only due to loss of intestinal surface area but also secondary to loss of inhibitory feedback mechanisms resulting in large volume diarrhea. 4 Overview of IF Location of Resection Malabsorption Fluid Losses Intestinal Transit Adaptation of Remaining Bowel Good ileal adaptation Poor jejunal adaptation Poor jejunal adaptation Poor jejunal adaptation Poor jejunal adaptation Jejunum Minimala Minimal Normal Ileum > 60 cm B12 Mild Rapid Ileum > 100 cm B12 and bile acids Fair to severe Mild Rapid Moderate to severe Severe Rapid Extensiveb (colon present) Extensiveb (colon absent) a b Severe Rapid Prognosis Good Fair Fair Fair to poor Poor Unless greater than 75% resected.