Colorectal Cancer (2006) - download pdf or read online

By Jim Cassidy, Patrick Johnston, Eric Van Cutsem

Written by means of international specialists at the topic, this reference comprehensively covers each element of colorectal melanoma. Addressing the molecular mechanisms, genetics, id, and remedy of disorder, this advisor covers new pharmaceutical advancements, present screening protocols, and smooth tools of ailment administration by way of experts at well known associations similar to the Royal Marsden health center, the Memorial Sloan Kettering melanoma middle, and the Vanderbilt-Ingram melanoma heart.

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Int J Cancer 1999; 84:404–409. 54. Messerini L, Ciantelli M, Baglioni S, Palomba A, Zampi G, Papi L. Prognostic significance of microsatellite instability in sporadic mucinous colorectal cancers. Hum Pathol 1999; 30:629–634. 55. Salahshor S, Kressner U, Fischer H, et al. Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor. Br J Cancer 1999; 81:190–193. 56. Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

The role of MYH is to remove the adenine that mispairs with 8-oxoguanine, which arises due to replication of oxidized DNA. Thus, defective MYH results in an increased rate of transversion of G:C to A:T (143), and this has been observed in human colorectal cancer. Indeed, the role of MYH defects in colorectal cancer was elucidated through the observation of the high rate of G:C to A:T somatic inactivating transversions in the APC gene (136). Family members subsequently shown to carry two common missense variants, (Y165C and G382D), in MYH, which affect highly conserved residues over several species including E.

78. Watanabe T, Wu T, Catalano PJ, et al. Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med 2001; 344:1196–1206. 79. Barratt PL, Seymour MT, Stenning SP, et al. DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study. Lancet 2002; 360:1381–1391. 80. Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.

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