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Edited by Knobil, E. D. 1179-1212. 3. S. Physiological actions of prolactin. In: Handbook of Physiology, Section 7, Vol. IV, Part 2, edited by Knobil, E. H. Bethesda, MD: American Physiological Society, 1974, pp. 253-292. 4. e. S. Hypothalamic-pituitary mediated modulation of immune function: Prolactin as a neuroimmune peptide. Br J Rheurnat 30:203-207, 1991. 5. , Ogata, K. and Takeuchi, S. J Biochern 95:1491-1499, 1984. 6. R. Decidual prolactin. Danish Medical Bulletin 37:154-165, 1990. 7. L.

WHOLE ANIMAL EVIDENCE. The lactotrope was one of the first cell types reported to express ER but not PRo This observation was ultimately reported in monkey,27,34 rat,40 and chicken. 27 Female cynomolgus macaques (Macaca JascicuZaris) were spayed in the early follicular phase and immediately implanted with Silastic capsules that were either empty (controls) or filled with estradiol (E-treated, 28 days). After 14 days, half of the E-treated monkeys received P-filled capsules for an additional 14 days (E only for 14 days, 12 Bethea et al followed by E + P for 14 days ).

Color Plate II contains photomicrographs that illustrate doublelabeled dopamine neurons in the dorsal and ventral arcuate nucleus. In summary, P cannot act transcriptionally on ventral ARC TIDA neurons to stimulate prolactin secretion because these neurons do not have nuclear PR. However, the frequency of PR-positive dopamine neurons in the periventricular (All) and dorsal arcuate (A12 dorsal) increased with E and P treatmentJ7 This data encouraged us to further investigation of the function of each of these populations during P-induced prolactin secretion, as described below.

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