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By Yu Heng Kwan

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Published by Elsevier Limited, 2014 35 Handbook of cosmeceutical excipients and their safeties Besides the lack of knowledge in consumers, the regulations and controls are limited in the cosmetic industry. The United States Food and Drug Administration (USFDA) is less stringent when it comes to regulating skin products (Karstadt, 2010). The Personal Care Products Council, a national trade association representing the global cosmetic and personal care products industry, set up the Cosmetic Ingredient Review (CIR) for reviewing ingredients in the market (Ross, 2006).

2006). Although other parameters such as the type of diffusion cell, temperature of skin, applied dose and diffusion area may affect the results, these diffusion cell models are nonetheless critical in the estimation of absorption of a compound as well as excipient characterization in transdermal dosage forms and cosmetics. Pig skin has been shown to most closely resemble human skin properties (Simon and Maibach, 2000), particularly with respect to permeation, skin thickness and lipid composition, and is available in abundance, usually from abattoirs.

Moreover, sample analysis is conducted only when the product is suspected of law violation. However, the FDA continues to stress the importance of complying with these guidelines to attain product safety assurance. In general, compliance to product safety is achieved if the cosmetic is not found to be adulterated or misbranded. In the US, guidelines or legislation pertaining to the compliance to product safety is less unambiguous compared to that in Europe or Singapore. The origin of the product, domestic or imported, has been taken into consideration by the FD&C Act.

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