Heparin and Related Polysaccharides - download pdf or read online

By Lennart Rodén, Sandya Ananth, Patrick Campbell, Tracy Curenton, Göran Ekborg (auth.), David A. Lane, Ingemar Björk, Ulf Lindahl (eds.)

This quantity is a checklist of a gathering entitled "Heparin and comparable Polysaccharides" that used to be held on the Biomedical middle, Uppsala, Sweden among 1-6 September 1991. The assembly was once hosted through U. Lindahl, L. Kjellen and that i. Bjork, who have been helped of their arrangements by way of a systematic advisory panel that incorporated U. Abildgaard, B. Casu, E. Holmer and D. Lane. Altogether, 230 contributors from 18 international locations attended the assembly, and such a lot have been current to be incorporated in a photo, that's to be came upon on the finish of this quantity. the choice of shows for inclusion within the Symposia of the assembly was once made at the foundation of the recognized prime quality of the paintings of the participants or teams concerned. This, we think, is mirrored within the contents of the enclosed articles, which jointly provide a finished review of the current nation of information of heparin and comparable compounds. a number of the components coated are evolving or debatable and the perspectives expressed in every one article will be considered as these of the author(s). The authors have taken a variety of quantities of care to outline all their abbreviations and a few familiarity with the several different types of nomenclature utilized in the fields of polysaccharide chemistry and of the coagulation proteinases and their inhibitors will help the reader.

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J. G. S. D. M. Weiler, J. Bioi. Chern. 263: 13090 (1988). G. C. R. Zetter and J. Folkman, J. Exp. Med. 152:931 (1980). B. Schreiber, J. J. Dowalski, R. Friesel, T. Mehlman and T. Maciag, Proc. Natl. Acad. Sci. 82: 6138 (1985). J. Folkman, R. J. Linhardt, C. Haudenschild and S. Taylor, ~ 221:719 (1983). R. Orem, S. Szabo and J. Folkman, ~ 230: 1375 (1985). D. R. Weintraub, Atherosclerosis 9:21 (1989). E. Coyne, Fed. Proc. 36:32 (1977). J. A. Ampofo, J. Fareed and J. Folkman, J. BioI. Chern. 1991, submitted.

The glycosidic linkages between hexosamine and uronic acid are broken resulting in an unsaturated uronic acid at the nonreducing end. 41 Purified heparin lyase has been used to prepare LMW heparins with retention of anticoagulant activity. 41 A commercial LMW heparin, Logiparin (Novo, Denmark), is also prepared using this method. A major disadvantage of this method is the unusual unsaturated uronic acid residue found in the non-reducing end of the chainS. 42 This residue may affect the rate of in vivo biotransformation of these chains.

113 (1990) abstr 174401y 15. van Ryn-McKenna. A. Ofosu. J. R. Buchanan. Antithrombotic and bleeding effects of glycosaminoglycans with different degrees of sulphation. Brit. J. 71: 265 (1989) 16. G. Meuleman. J. Hobbelen. G. van Dinther. T. Vogel. A. T. Moelker. Antifactor Xa activity and antithrombotic activity in rats of structural analogues of the minimum antithrombin III binding sequence: discovery of compounds with a longer duration of action than of the natural pentasaccharide. Seminars Thromb.

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