Download e-book for kindle: Histopathology of Non-Hodgkin’s Lymphomas: Based on the by Prof. Dr. Dr. h.c. mult. Karl Lennert, Prof. Dr. Alfred

By Prof. Dr. Dr. h.c. mult. Karl Lennert, Prof. Dr. Alfred Christian Feller (auth.)

The 1st variation of Histopathology of Non-Hodgkin's Lymphomas, written in col­ laboration with Professor H. STEIN and released in 1981, used to be got good and is now out of print. meanwhile, there was an explosion of information that not just have made the definitions of assorted entities extra exact yet, in particular, have proven the most entities initially delineated within the Kiel class. the improvement of monoclonal antibodies and molecular cytogenetics has additionally made it attainable to spot T-cell lymphomas extra thoroughly. for instance, some of the malignant lymphomas that have been formerly thought of to be unclas­ sifiable can now be incorporated in a type scheme that locations the T-cell lymphomas along of the record of B-cell lymphomas. In 1988 the eu Lymphoma membership released an "updated Kiel category" (STANSFELD et al. 1988) according to this new wisdom. It encompasses a variety of formerly undefined sorts of T-cell lymphoma. experiences performed in Japan (T. SUCH! et al.) and China (L. Y Tu) have contributed to the certainty of those lymphoma types.

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Extra info for Histopathology of Non-Hodgkin’s Lymphomas: Based on the Updated Kiel Classification

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96. __ ~ __- - J 108. mo nths 120. Fig. 17. Overall survival probability of patients with advanced non-Hodgkin's lymphoma (stage III/IV according to the Ann Arbor classification) diagnosed according to the Kiel classification. Results of a prospective observation trial carried out by the Kiel Lymphoma Study Group (1975 -1980). The low plateau level of survival of patients with high-grade malignant lymphoma is due to the polychemotherapy of merely moderate intensity (predominantly COP ± methotrexate; C-MOPP) employed in this study, which started recruiting patients in 1975.

1979. Lennert et al. 1983. 32 The Kie1 Classification the beginning of their development, germinal centres consist exclusively of centroblasts; centrocytes do not appear untillater. 90 An updated, convincing concept of germinal centre development has been presented by MACLENNAN. 91 Besides the typical centro blasts and centrocytes, germinal centres contain several other cell types that are often easier to identify by electron microscopy than in immunohistochemically stained slides. New germinal centres and the dark zone of the later developmental phase show basophilic, medium-sized or large cells with multiple, central nucleoli.

It is not possible to calculate the ratio of B-cell lymphomas to T-cell lymphomas in childhood on the basis of our data, because not all cases were examined immunohistochemically. An immunohistochemical analysis would be absolutely necessary in the cases of immunoblastic, lymphoblastic and large cell 109 Bucsky et al. 1988; cf. Bucsky et al. 1989, 1990. 45 Statistical Data Table 13. Non-Hodgkin's lymphomas diagnosed on nodal and extranodal biopsies from children and adolescents (under the age of 18 years) during two clinical studies (NHL-BFM) in 1981 and 1983 (n = 262).

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