By Miranda L. Michelli
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Extra info for Liver Cirrhosis: Causes, Diagnosis and Treatment (Hepatology Research and Clinical Developments)
2005) afforded synergistic and significant necrosis and growth inhibitory effects on tumors, reduced angiogenesis and metastasis. These experimental results encouraged the Tha assessment in clinical trials. Tha effects in clinical evaluations for treating HCC have yielded varied outcomes. , 2006). , 2008). , 2005). , 2004). Adverse Effects by Thalidomide: Hepatotoxicity As commented above, Tha is a relatively safe drug compared with other known teratogens due to its very low acute toxicity, LD50 of >5000 mg/kg in mice and rabbits (Somers, 1960; Williams, 1968).
Biochim Biophys Acta, 2000;1482:157-71. Fujimoto, H; Noguchi, T; Kobayashi, H; Miyachi, H; Hashimoto, Y. Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on celldifferentiation, cyclooxygenase activity and angiogenesis. Chem Pharm Bull. 2006;54:855-60. Fujita, J; Mestre, JR; Zeldis, JB; Subbaramaiah, K; Dannenberg, AJ. Thalidomide and its analogues inhibit lipopolysaccharide-mediated Iinduction of cyclooxygenase-2. Clin Cancer Res. 2001;7:3349-55. Fullerton, PM; Kremer, M.
Synthesis and biological evaluation of nitric oxide-donating thalidomide analogues as anticancer agents. Chem Biodivers. 2009;6:466-74. Williams, RT. Thalidomide: a study of biochemical teratology. Arch Environ Health, 1968;16:493-502. Witjes, CD; Verhoef, C; Verheul, HM; Eskens, FA. '. Neth J Med. 2009;67:86-90. Wnendt, S; Finkam, M; Winter, W; Ossig, J; Raabe, G; Zwingenberger, K. Enantioselective inhibition of TNF-α release by thalidomide and thalidomide analogues. Chirality, 1996;8:390-6. Xiao, YJ; Luo, HS; Lv, P.