By Wilbur A. Smith
It's the age of empire, of blood and conquest, of boundless pleasure and probability. Striding within the footsteps of the pioneers is Zouga Ballantyne. His dream starts within the threat and drudgery of the diamond pits and finally ends up at the wealthy grasslands of Matabeleland - yet now not earlier than a king and a proud warrior state have paid the cost of history...
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Additional info for Men of Men (Ballentyne, Book 2)
Even the existence of chemical transmission of nerve impulses in coelenterates has not yet been established. In the course of 400 million years of independent development Nature has found not only the chemical principle of transmission of nervous excitation, but also ACh as one of the mediators for both main branches of the phylogenetic tree. Among the examples of all types of animals, in which this question has been studied, ACh is not the only mediator. e. noradrenaline with a small admixture of adrenaline), glutamic acid, gamma-amino-butyric acid, glycine and possibly 5-hydroxytryptamine (serotonin).
This would also simplify the interpretation of results. In recent years alkylating agents have been obtained which, like dibenamine, contain a 2-chlorethylamine grouping, but which have a more selective action on the ChR than dibenamine—preparations (XIII) and (XVI), for example. Dibenamine rapidly cyclizes in solution with the formation of ethylene-iminium ion, which is the alkylating agent (Nickerson, 1949). The same cyclization process takes place also with other substances containing the 2-chlorethylamine group (compare, for example, preparations (XIII) and (XVI).
9 1962). It was later shown, however, that the conclusion that gallamine had an affinity for hyaluronic acid was the result of inadequately conducted experiments. Thus, the equilibrium dialysis was carried out with distilled water instead of a physiological solution, and in these 33 34 ACETYLCHOLINE conditions hyaluronic acid bound the gallamine cations very firmly, but quite non-specifically. Equilibrium dialysis in dilute salt solutions revealed no affinity of the mucopolysaccharides for quaternary ammonium compounds (see Ehrenpreis et aL, 1969).