K. Tatemoto (auth.), Professor Martin C. Michel (eds.)'s Neuropeptide Y and Related Peptides PDF

By K. Tatemoto (auth.), Professor Martin C. Michel (eds.)

After a bit greater than twenty years because the unique discovery of neuropeptide Y (NPY) by means of Tatemoto and associates, the sphere of NPY study has made impressive development and is coming of age.The current quantity addresses all significant themes in reference to NPY and similar peptides through tested leaders of their respective parts. skilled NPY-aficionados will surely locate new and important more information during this quantity and rookies to the sector will optimistically realize how a lot interesting study this nonetheless has to offer.

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2002), was first shown by the observation that they constitute the specific targets for clostridial neurotoxins, which inhibits neurotransmitter release (Link et al. 1992; Blasi et al. 1993). Further studies have established that the docking event requires the assembly of SNARE complexes, which are composed of proteins that are anchored to each of the membranes that are destined to fuse (Chapman et al. 2002). The SNARE complex drives the LDCV into direct contact with the cell membrane. Subsequently, an energy wasting process is initiated to finally make the vesicles competent for the final step in exocytosis, the fusion with the cell membrane (Klenchin et al.

M. Alfalalr' . C. D. Wranrr' . T. Karl l . R. Pabst' S. de 2 Probiodrug AG, 06120 Halle, Germany 3 Department of Physiological Chemistry, School of Veterinar y Medicine, 30559 Hannover , Germany I Introduction . . . . . . . . . 24 2 Storage and Synthesis of PP, PYYand NPY . 1 Large Vesicles . 2 Small Vesicles . 2 Posttranslational Modification . 26 26 26 27 27 3 Localization and Release of NPY, PYYand PP in the Periphery. 1 Cellular Sources for NPYand Release in the Periphery . 1 Sympathetic Nerves.

Regul Pept 85:9-24 Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev 50:143-150 Morris JL, Gibbins IL, Furness JB, Costa M, Murphy R (1985) Co-localization of neuro peptide Y, vasoactive intestinal polypeptide and dynorphin in non-noradrenergic axons of the guinea pig uterine artery.

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