Download e-book for kindle: Pediatric Inflammatory Bowel Disease by Petar Mamula, Andrew B. Grossman, Robert N. Baldassano,

By Petar Mamula, Andrew B. Grossman, Robert N. Baldassano, Judith R. Kelsen, Jonathan E. Markowitz

This textbook will emphasize the pediatric points of IBD together with the diagnostic process; specified food; development; bone density in addition to psychosocial concerns which are diverse, and should no longer exist in adults. Chapters will comprise IBD genetics, immunology, epidemiology, pharmacogenomics, prognosis (clinical, laboratory, radiologic, histologic and endoscopic), dietary and progress features, psychosocial matters, extraintestinal manifestations, and administration (divided into clinical, dietary and surgical remedy) with exact emphasis on new biologic therapeutics. numerous brief chapters will tackle problems with perianal IBD, melanoma surveillance, replacement remedy and transition to grownup care. An emphasis may be put on visible aides in the textbook within the type of tables, figures, schemes, algorithms, in addition to endoscopy and surgical procedure photographs.

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The vast majority of these challenges comes from the external environment and, in the specific case of the gastrointestinal tract, they include foods, the commensal flora, microbial pathogens and xenobiotics. What protects the intestine from such a large and permanent antigenic load is the mucosal immune system, explaining why this makes up the largest and most varied collection of immune cells of the body. Not only the antigenic challenge to the gut is massive and continuous, but it also occurs at the largest area of interface with the external milieu, as the total surface of the gastrointestinal tract is roughly equal to that of a tennis court (400 m2 ).

Inflammatory Bowel Diseases 2005;11(7):639–44. 67. Wine E, Reif SS, Leshinsky-Silver E, et al. Pediatric Crohn disease and growth retardation: the role of genotype, phenotype, and disease severity. Pediatrics 2004;114(5):1281–6. 68. Russell RK, Drummond HE, Nimmo EE, et al. Genotype-phenotype analysis in childhood-onset Crohn disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease. Inflammatory Bowel Diseases 2005;11(11):955–64. 69. Roesler J, Thurigen A, Sun L, et al.

15. Kobayashi KS, Chamaillard M, Ogura Y, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005;307(5710):731–4. 16. Economou M, Trikalinos TA, Loizou KT, Tsianos EV, Ioannidis JP. Differential effects of NOD2 variants on Crohn disease risk and phenotype in diverse populations: a metaanalysis. The American Journal of Gastroenterology 2004;99(12):2393–04. 17. Cummings JR, Jewell DP. Clinical implications of inflammatory bowel disease genetics on phenotype.

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