By Allan Eckert
An epic novel via an award-winning writer chronicles the settling of the Ohio River Valley, domestic to the defiant Shawnee Indians, who vow to guard their land opposed to the possible unstoppable.
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Additional info for That Dark and Bloody River: Chronicles of the Ohio River Valley
Presumably in the mice with heterotopic pituitaries this thyrotrophin already is being secreted at maximal rate since thyroid weight is not maintained above the hypophysectomy level and the production of thyroxine in these animals is considerably below that of normal controls. This does not seem to be the case, however. Lowering the blood thyroxine level by the chronic administration of propylthiouracil or increasing it by the injection of thyroxine will result in a marked change in thyroidal radioiodine metabolism of the implanted animals and considerable cytological transformation without a corresponding alteration of thyroid size.
MILLAR Copyright 0 1957 Ciba Foundation CONTRIBUTION T O T H E REGULATION OF THYROID ACTIVITY R. COURRIER Laboratoire de Morphologie Expe'rimentale et Eudocrinologie, Collige de France, Paris IN the Collbge de France we have carried out various investigations on the regulation of thyroid activity. To begin with, a simple and reliable procedure is required t o measure this activity. We take advantage of a fact which we noticed in 1944 (Joliot, Courrier, Horeau and Sue). I n the blood, a discrimination is made by the red blood cell between inorganic iodine and hormonal iodine : whereas the former is distributed between the plasma and the cells, the latter remains in the plasma.
These data seem t o favour a direct mode of action of 26 R. COURRIER thyroxine on the anterior pituitary. But is one allowed to postulate that the pituitary, separated from the hypothalamus, is entirely deprived of any hypothalamic secretion? We face here the great problem of the hypothalamus-pituitary relationships and of the action of the neurosecretion by the portal vessels. It is quite definite that the hypothalamus acts on the thyroid by a pituitary pathway. Hypophyseal grafts, hypothalamic lesions, and electrical stimulation of the hypothalamus have demonstrated this quite extensively.