Download e-book for iPad: The Immunology of Human Pregnancy by Henry N. Claman

By Henry N. Claman

...the writing is superb...the most intricate immunologic strategies are provided in easy-to-folow diagrams...clinicians who care for ladies attempting to have infants, graduate scholars, postdoctoral fellows, and scientific citizens wanting a uncomplicated wisdom of being pregnant immunology might locate this booklet a helpful asset.-The New England magazine of drugs

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Extra resources for The Immunology of Human Pregnancy

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B cells use as their antigenspecific receptor the surface Ig molecules that constitute the specificity of their particular clone. (B cells can also be activated nonspecifically via mitogens. These include llokeweed mitogen (PWM) and anti- immunoglobulins. ) Some B cells can interact directly with certain antigens, and there is apparently little if any need for APCs or auxiliary T cell activity. This is called T-independent antibody formation. It is characteristic oflarge antigens with repeating antigenic determinants, such as dextran.

5 54 Materna-Fetal Relationships When the components of the extravillous trophoblast were similarly studied, the results were somewhat different. Extravillous trophoblast stained strongly with anti-HLA class I antibodies, such as W6/32, yet they failed to stain with antibodies to antigens specific for paternal antigens. li1 stain trophoblast cells were antibodies against the nonpolymorphic (invariant) parts of the HLA molecule. By contrast, the antibodies that did not stain trophoblast cells were directed against the individual HLA specificities expressed on the amino-terminal ends of the molecules.

23 Unlike T cells, the gene rearrangements leading to the formation of complete genes for the heavy and light chains can undergo somatic mutation during the course of the antibody response. B cells use as their antigenspecific receptor the surface Ig molecules that constitute the specificity of their particular clone. (B cells can also be activated nonspecifically via mitogens. These include llokeweed mitogen (PWM) and anti- immunoglobulins. ) Some B cells can interact directly with certain antigens, and there is apparently little if any need for APCs or auxiliary T cell activity.

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